M. Yamazaki
Blackwell Science,1996 [ISBN 0632042729]
Medicinal Chemistry: Today and Tomorrow presents
the edited proceedings of the AFMC International Medicinal Chemistry
Symposium. Medicinal chemistry is an interdisciplinary science covering
a broad range of subjects but with chemistry as its core. The goal of
medicinal chemistry is to produce effective new pharmaceuticals. The
subject has seen remarkable advances in recent years, and Medicinal
Chemistry: Today and Tomorrow provides a synthetic overview of the state
of the art. This volume should make an important contribution to medicinal
chemistry in its quest to produce innovative drugs that make the best
use of recent developments in pharmaceutical research.
Contents
Preface; Antitumor taxoids; Prospects for
pharmaceuticals from marine organisms; New lead structures in pharmacophore-based
drug design; Targeting delivery of prostanoids and bioactive proteins;
Cytokine receptors as a new tool for therapy of inflammation; Functional
analysis of glutamate receptors by drug-based molecular approaches;
Biologically active microbial metabolites; Total synthesis of natural
products and designed molecules: brevetoxin B; Enzyme inhibitors for
the treatment of AIDS; New approaches to the synthetic problems of myo-inositol
phosphates and their biological utilities; Industrial bioconversions
for chiral molecules, issues and developments; A new class of an orally
active antidiabetic agent, insulin action enhancer: the development
of Troglitazone; Kappa agonist phenothiazines: synthesis and SAR; A
new class of diacidic nonpeptide angiotensin II receptor antagonists;
Synthetic studies using sulfate radicals generated from peroxysulfates;
Cataloytic
asymmetric carbon-carbon bond-forming reaction utilizing rare earth
metal complexes; Design and development of practical asymmetric syntheses
of drug candidates; Search for biologically active compounds from tropical
plants; Marine pharmaceuticals: receptor/ligand interactions and cell
signalling; Bioactive constituents of Chinese traditional medicine;
An integrated approach to exploiting molecular diversity; Structures
and functions of prostanoid receptors; Allylic nitro-oximes: an
original moiety pattern to store and release nitric oxide; Design and
synthesis of novel potent, non-peptide and orally active renin inhibitors;
Inhibition of HIV proteinase; Drug metabolism and toxicokinetics; Calcium-mediated
mechanisms in chemically induced cell death; Targeted drug delivery
to the brain using chemical delivery systems; Rational design of peptides
with enhanced membrane permeability; Review on the development of a
polymer conjugate drug: SMANCS; Moedulation of the carnohydrate structures
of recombinant human glycoprotein therapeutics; Role of sphingoglycolipids
in signal transduction, and their medicinal application for control
of tumor progression
and inflammatory processes; Recent aspects of glycoconjugates synthesis:
orthogonal glycosylation strategy; Chemical aspects of artificial gene
regulatory molecules; Integrin adhesion receptors as targets for medicinal
chemistry; Towards an orphan drug policy for the European Union; Support
for orphan drug development: legislation in the United States, Japan
and Europe; System for the orphan drug development in Japan; Design
and pharmacological evaluation of a series of non-peptide endothelin
ETA selective and ETA/ETB receptor antagonists; The DNA gyrase inhibitor
cyclothialidine: progenitor of a new class of antibacterial agents;
Novel AMPA/kainate receptor antagonists
153 illustrations
288 pages
© 1998 Blackwell Science
Ltd