27 No. 1
Compendium of Targets of the Top 100 Commercially Important Drugs
Published articles on drug discovery frequently point out that most commercially successful pharmaceutical agents act on a relatively small number of molecular targets. However, there does not appear to be a resource where compiled target information is readily available in a single location.
The goal of this project is to provide a resource containing the following information on the targets of the most commercially important drugs: type of target (enzyme, receptor, etc.); brief description of relevance to disease or indication; reference to knockout information, if available; reference to structural information, if available; listing of the marketed drugs that interact with the target along with potency and relevant selectivity information. It is anticipated that this compendium will be a valuable teaching and reference source for the drug discovery community.
For more information, contact the Task Group Chairman, John Proudfoot <[email protected]>.
last modified 13 December 2004.
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