Detection of pharmacologically active natural products using ecology. Selected examples from Indopacific marine invertebrates and sponge-derived fungi
P. Proksch, R. Ebel, R. A. Edrada, P. Schupp, W. H. Lin, Sudarsono, V. Wray, and K. Steube
1Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität
Düsseldorf,
Universitätsstrasse 1 Geb. 26.23, D-40225 Düsseldorf, Germany;
2Centre for Marine Biofouling and Bio-Innovation, University of New
South Wales, Sydney, 2052 Australia; 3National Research Laboratories
of Natural and Biomimetic Drugs, Peking University, No. 8 Xueyang Road,
100083 Beijing, PR China; 4Centre for Traditional Medicine, Gadjah Mada
University, Yogyakarta 55281, Indonesia; 5Gesellschaft für Biotechnologische
Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany; 6DSMZ,
Mascheroder Weg 1b, D-38124 Braunschweig, Germany
Abstract: This review article presents our group's
recent research findings with regard to bioactive natural products from
marine sponges and tunicates, as well as from sponge derived fungi.
The organisms discussed originate in the Indopacific region, which has
an exceptionally rich marine biodiversity. Major topics that are covered
in our review include the chemical ecology of sponges, focusing on defense
against fishes, as well as the isolation and identification of new bioactive
constituents from sponges and tunicates. Sponge derived fungi are introduced
as an emerging source for new bioactive metabolites, reflecting the
currently growing interest in natural products from marine microorganisms.
*Pure Appl.Chem. 75,
141�419 (2003). An issue of reviews and research papers based on
lectures presented at the 23rd IUPAC International Symposium on the
Chemistry of Natural Products, Florence, Italy, 28 July � 2 August 2002.
