I  U  P  A  C




News & Notices

Organizations & People

Standing Committees




. . CI
. . PAC
. . Macro. Symp.

. . Books
. . Solubility Data



Links of Interest

Search the Site

Home Page


Pure Appl. Chem. Vol. 75, Nos. 11-12, 1617-2615 (2003)

Pure and Applied Chemistry

Vol. 75, Issues 11-12


Special Topic Issue on the Implications of Endocrine Active Substances for Humans and Wildlife

J. Miyamoto and J. Burger* (Editors)
Associate Editors: John Ashby, William Kelce, Werner Klein, Kenneth Korach, James Lamb, and Peter Matthiessen

Preface, J. Burger
Dedication, J. Bruger
Executive Summary (16 pages) [pdf file - 326KB], J. Miyamoto and J. Burger

Topic 1 Molecular Mode of Action of Nuclear Receptors: Fundamentals for Understanding the Action of Endocrine Active Substances

Nuclear receptor superfamily: Principles of signaling
P. Germain, L. Altucci, W. Bourguet, C. Rochette-Egly, and H. Gronemeyer
p. 1619 [Abstract] [full text - pdf 3.55MB]

Nuclear receptor coregulators
N. J. McKenna and B. W. O'Malley
p. 1665 [Abstract] [full text - pdf 164KB]

Function and mode of action of nuclear receptors: Estrogen, progesterone, and vitamin D
E. A. Kimbrel and D. P. McDonnell
p. 1671 [Abstract] [full text - pdf 274KB]

Biological function and mode of action of the androgen receptor
E. M. Wilson
p. 1685 [Abstract] [full text - pdf 178KB]

Genetic dissection of gluco- and mineralocorticoid receptor function in mice
E. F. Greiner, S. Berger, and G. Schütz
p. 1699 [Abstract] [full text - pdf 244KB]

Functions of RARs and RXRs in vivo: Genetic dissection of the retinoid signaling pathway
M. Mark and P. Chambon
p. 1709 [Abstract] [full text - pdf 265KB]

Biological function and mode of action of nuclear xenobiotic receptors
J. Sonoda and R. M. Evans
p. 1733 [Abstract] [full text - pdf 214KB]

Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling
D. Picard
p. 1743 [Abstract] [full text - pdf 218KB]

Estrogen receptor action through target genes with classical and alternative response elements
P. J. Kushner, P. Webb, R. M. Uht, M.-M. Liu, and R. H. Price, Jr.
p. 1757 [Abstract] [full text - pdf 466KB]

Nuclear receptor action involved with sex differentiation
I. A. Hughes, H. Martin, J. Jääskeläinen, and C. L. Acerini
p. 1771 [Abstract] [full text - pdf 329KB]

Human disorders caused by nuclear receptor gene mutations
J. C. Achermann and J. L. Jameson
p. 1785 [Abstract] [full text - pdf 294KB]

Interactions of exogenous endocrine active substances with nuclear receptors
J. A. Katzenellenbogen and R. Muthyala
p. 1797 [Abstract] [full text - pdf 377KB]

Transcriptional roles of AhR in expression of biological effects induced by endocrine disruptors
Y. Fujii-Kuriyama and J. Mimura
p. 1819 [Abstract] [full text - pdf 200KB]

Nonmammalian nuclear receptors: Evolution and endocrine disruption
J. W. Thornton
p. 1827 [Abstract] [full text - pdf 211KB]

Topic 2 Environmental Fate and Metabolism of Endocrine Active Substances

Analysis of endocrine active substances in food and the environment
P. T. Holland
p. 1843 [Abstract] [full text - pdf 210KB]

Naturally produced steroid hormones and their release into the environment
L. S. Shore and M. Shemesh
p. 1859 [Abstract] [full text - pdf 173KB]

Concentration of phytohormones in food and feed and their impact on the human exposure
Ph. Verger and J. C. LeBlanc
p. 1873 [Abstract] [full text - pdf 160KB]

Pharmaceuticals and personal care products - A source of endocrine disruption in the environment?
F. Ingerslev, E. Vaclavik, and B. Halling-Sørensen
p. 1881 [Abstract] [full text - pdf 224KB]

Endocrine active industrial chemicals: Release and occurrence in the environment
A. Johnson and M. Jürgens
p. 1895 [Abstract] [full text - pdf 166KB]

Release of pesticides into the environment and initial concentrations in soil, water, and plants
K. D. Racke
p. 1905 [Abstract] [full text - pdf 172KB]

Role of metabolism in the endocrine-disrupting effects of chemicals in aquatic and terrestrial systems
M. van den Berg, T. Sanderson, N. Kurihara, and A. Katayama
p. 1917 [Abstract] [full text - pdf 311KB]

Critical factors in exposure modeling of endocrine active substances
P. de Voogt and B. van Hattum
p. 1933 [Abstract] [full text - pdf 245KB]

Environmental fate and metabolism: Issues and recommendations
P. de Voogt, B. Halling-Sørensen, B. van Hattum, P. T. Holland, F. Ingerslev, A. Johnson, M. Jürgens, A. Katayama, W. Klein, N. Kurihara, J. C. Leblanc, K. D. Racke, T. Sanderson, M. Shemesh, L. S. Shore, et. al.
p. 1949 [Abstract] [full text - pdf 139KB]

Topic 3 Effects of Endocrine Active Chemicals in Rodents and Humans, and Risk Assessments for Humans

Interactions of xenobiotics with the steroid hormone biosynthesis pathway
T. Sanderson and M. van den Berg
p. 1957 [Abstract] [full text - pdf 290KB]

Organochlorine compounds and breast cancer risk
M. A. Mendez and L. Arab
p. 1973 [Abstract] [full text - pdf 271KB]

Prevention of ambiguous genitalia by prenatal treatment with dexamethasone in pregnancies at risk for congenital adrenal hyperplasia
M. I. New
p. 2013 [Abstract] [full text - pdf 382KB]

Male reproductive disorders and the role of endocrine disruption: Advances in understanding and identification of areas for future research
R. M. Sharpe and N. E. Skakkebaek
p. 2023 [Abstract] [full text - pdf 219KB]

Brominated flame retardants and endocrine disruption
J. G. Vos, G. Becher, M. van den Berg, J. de Boer, and P. E. G. Leonards
p. 2039 [Abstract] [full text - pdf 214KB]

Toxicity vs. beneficial effects of phytoestrogens
H. Wanibuchi, J. S. Kang, E. I. Salim, K. Morimura, and S. Fukushima
p. 2047 [Abstract] [full text - pdf 151KB]

Evaluation of thyroid function in neonatal and adult rats: The neglected endocrine mode of action
M. S. Christian and N. A. Trenton
p. 2055 [Abstract] [full text - pdf 231KB]

Modification of endocrine active potential by mixtures
K. Gaido, L. You, and S. Safe
p. 2069 [Abstract] [full text - pdf 242KB]

Experience with new testing guidelines with endocrine-sensitive end-points
R. W. Tyl
p. 2081 [Abstract] [full text - pdf 386KB]

Critical evaluation of observed adverse effects of endocrine active substances on reproduction and development, the immune system, and the nervous system
J. C. O'Connor and R. E. Chapin
p. 2099 [Abstract] [full text - pdf 296KB]

Significance of experimental studies for assessing adverse effects of endocrine-disrupting chemicals
L. E. Gray, Jr. and P. M. D. Foster
p. 2125 [Abstract] [full text - pdf 360KB]

Determination of acceptable exposure levels for humans for endocrine active substances: Use of animal models
P. A. Fenner-Crisp
p. 2143 [Abstract] [full text - pdf 149KB]

Use of NOAEL, benchmark dose, and other models for human risk assessment of hormonally active substances
R. W. Setzer, Jr. and C. A. Kimmel
p. 2151 [Abstract] [full text - pdf 160KB]

Endocrine active substances and dose response for individuals and populations
H. A. Barton
p. 2159 [Abstract] [full text - pdf 167KB]

Endocrine disruption occurring at doses lower than those predicted by classical chemical toxicity evaluations: The case bisphenol A
J. Ashby
p. 2167 [Abstract] [full text - pdf 286KB]

Environmental estrogens and sperm counts
H. Fisch and R. Golden
p. 2181 [Abstract] [full text - pdf 177KB]

Topic 4 Effects of Endocrine Active Substances in Wildlife Species

Historical perspective on endocrine disruption in wildlife
P. Matthiessen
p. 2197 [Abstract] [full text - pdf 173KB]

Endocrine disruption in invertebrates
J. Oehlmann and U. Schulte-Oehlmann
p. 2207 [Abstract] [full text - pdf 395KB]

Endocrine disruption in wild freshwater fish
S. Jobling and C. R. Tyler
p. 2219 [Abstract] [full text - pdf 373KB]

Effects of endocrine disruptors in aquatic mammals
M. C. Fossi and L. Marsili
p. 2235 [Abstract] [full text - pdf 411KB]

Endocrine disruption in marine fish
P. Matthiessen
p. 2249 [Abstract] [full text - pdf 184KB]

Deformed frogs and environmental retinoids
D. Gardiner, A. Ndayibagira, F. Grün, and B. Blumberg
p. 2263 [Abstract] [full text - pdf 225KB]

Contaminant-induced endocrine and reproductive alterations in reptiles
L. J. Guillette, Jr. and T. Iguchi
p. 2275 [Abstract] [full text - pdf 344KB]

Review of the effects of endocrine-disrupting chemicals in birds
J. P. Giesy, L. A. Feyk, P. D. Jones, K. Kannan, and T. Sanderson
p. 2287 [Abstract] [full text - pdf 200KB]

Wildlife as models for the study of how mixtures, low doses, and the embryonic environment modulate the action of endocrine-disrupting chemicals
D. Crews, O. Putz, P. Thomas, T. Hayes, and K. Howdeshell
p. 2305 [Abstract] [full text - pdf 193KB]

Interactions of endocrine-disrupting chemicals with stress responses in wildlife
T. G. Pottinger
p. 2321 [Abstract] [full text - pdf 180KB]

Effects of endocrine active substances in wildlife species: Genetic, biochemical, and physiological factors in variable susceptibility to endocrine disruptors
S. Kawai, M. Kobayashi, and H. Kaneko
p. 2335 [Abstract] [full text - pdf 233KB]

Development of fish tests for endocrine disruptors
T. H. Hutchinson, H. Yokota, S. Hagino, and K. Ozato
p. 2343 [Abstract] [full text - pdf 305KB]

Endocrine disruption in wildlife: The future?
J. P. Sumpter
p. 2355 [Abstract] [full text - pdf 129KB]

Workshop 1 Effectiveness of QSAR for Prescreening of Endocrine Disruptor Hazard

Mechanism-based QSAR approach to the study of the toxicity of endocrine active substances
C. D. Selassie, R. Garg, and S. Mekapati
p. 2363 [Abstract] [full text - pdf 231KB]

Regulatory application of SAR/QSAR for priority setting of endocrine disruptors: A perspective
W. Tong, H. Fang, H. Hong, Q. Xie, R. Perkins, J. Anson, and D. M. Sheehan
p. 2375 [Abstract] [full text - pdf 528KB]

QSAR prioritization of chemical inventories for endocrine disruptor testing
P. Schmieder, O. Mekenyan, S. Bradbury, and G. Veith
p. 2389 [Abstract] [full text - pdf 186KB]

The nature of the ligand-binding pocket of estrogen receptor alpha and beta: The search for subtype-selective ligands and implications for the prediction of estrogenic activity
J. A. Katzenellenbogen, R. Muthyala, and B. S. Katzenellenbogen
p. 2397 [Abstract] [full text - pdf 413KB]

Fragment molecular orbital study of the binding energy of ligands to the estrogen receptor
K. Fukuzawa, K. Kitaura, K. Nakata, T. Kaminuma, and T. Nakano
p. 2405 [Abstract] [full text - pdf 241KB]

Workshop 2 Toxicogenomics as a Rational Approach to Endocrine Disruptor Research

Toxicogenomics: Impact on human health
J. K. Selkirk
p. 2413 [Abstract] [full text - pdf 109KB]

Temporal responses to estrogen in the uterus
K. C. Fertuck and T. R. Zacharewski
p. 2415 [Abstract] [full text - pdf 136KB]

Application of toxicogenomics to the endocrine disruption issue
T. Shirai and M. Asamoto
p. 2419 [Abstract] [full text - pdf 145KB]

Transcript profiles elicited by developmental exposure to endocrine-mediated toxicants
G. Daston
p. 2423 [Abstract] [full text - pdf 141KB]

Use of gene expression profiling to understand the transcriptional program associated with estrogen-induced uterine growth
J. G. Moggs, D. G. Deavall, and G. Orphanides
p. 2429 [Abstract] [full text - pdf 137KB]

Workshop 3 The Need for Establishing Integrated Monitoring Programs

Need for establishing integrated programs to monitor endocrine active compounds
H. Segner
p. 2435 [Abstract] [full text - pdf 167KB]

Search for the evidence of endocrine disruption in the aquatic environment; Lessons to be learned from joint biological and chemical monitoring in the European project COMPREHEND
R. I. L. Eggen, B.-E. Bengtsson, C. T. Bowmer, A. A. M. Gerritsen, M. Gibert, K. Hylland, A. C. Johnson, P. Leonards, T. Nakari, L. Norrgren, J. P. Sumpter, M. J.-F. Suter, A. Svenson, and A. D. Pickering
p. 2445 [Abstract] [full text - pdf 146KB]

Biomonitoring: Integration of biological end-points into chemical monitoring
M. Seifert, L. Wen, M. Alberti, U. Kausch, and B. Hock
p. 2451 [Abstract] [full text - pdf 487KB]

Identifying the causative agents: The use of combined chemical and biological strategies in monitoring programs
E. J. Routledge
p. 2461 [Abstract] [full text - pdf 142KB]

Closing the gap between exposure and effects in monitoring studies
D. E. Tillitt and D. M. Papoulias
p. 2467 [Abstract] [full text - pdf 159KB]

Workshop 4 Simple, Rapid Assay for Conventional Definitive Testings of Endocrine Disruptor Hazard

Simple, rapid assays for conventional definite testing of endocrine disruptor hazard: Summary and recommendations
S. Fukushima and A. Freyberger
p. 2479 [Abstract] [full text - pdf 118KB]

Testing of endocrine active substances using an enhanced OECD test guideline 407: Experiences from studies on flutamide and ethinylestradiol
A. Freyberger, P. Andrews, E. Hartmann, R. Eiben, I. Loof, U. Schmidt, M. Temerowski, A. Folkerts, M. Becka, B. Stahl, and M. Kayser
p. 2483 [Abstract] [full text - pdf 144KB]

Application of rat medium-term bioassays for detecting carcinogenic and modifying potentials of endocrine active substances
K. Imaida, S. Tamano, A. Hagiwara, S. Fukushima, T. Shirai, and N. Ito
p. 2491 [Abstract] [full text - pdf 182KB]

Enhanced one-generation reproductive toxicity study in rats for detecting endocrine-disrupting effects of chemicals
H. Aoyama and K. Suzuki
p. 2497 [Abstract] [full text - pdf 153KB]

Workshop 5 Precautionary Principle/Approach and Weight of Evidence in Endocrine Disruptor Issues

Making decisions in the 21st century: Scientific data, weight of evidence, and the precautionary principle
J. Burger
p. 2505 [Abstract] [full text - pdf 172KB]

Precautionary principle and endocrine active substances
B. D. Goldstein
p. 2515 [Abstract] [full text - pdf 123KB]

Why epidemiology of endocrine disruptors warrants the precautionary principle
M. Gochfeld
p. 2521 [Abstract] [full text - pdf 139KB]

General process for the risk assessment of pesticides that interact with or affect the endocrine system
K. Hamernik
p. 2531 [Abstract] [full text - pdf 117KB]

Role of the precautionary principle in the EU risk assessment process on industrial chemicals
J. de Bruijn, B. Hansen, and S. Munn
p. 2535 [Abstract] [full text - pdf 126KB]

Differing perspectives on the use of scientific evidence and the precautionary principle
J. Burger
p. 2543 [Abstract] [full text - pdf 113KB]

Workshop 6 Risk Management Options for Endocrine Disruptors in National and International Programs

Risk management options for endocrine disruptors in national and international programs
J. C. Lamb, IV, H. B. W. M. Koëter, R. Becker, A. Gies, L. Davies, T. Inoue, A. Jacobs, G. Lyons, M. Matsumoto, and G. Timm
p. 2549 [Abstract] [full text - pdf 137KB]

Hormonally active agents and plausible relationships to adverse effects on human health
T. Inoue
p. 2555 [Abstract] [full text - pdf 127KB]

Government view of endocrine disruption in wildlife
A. Gies
p. 2563 [Abstract] [full text - pdf 153KB]

Risk perception: A chemical industry view of endocrine disruption in wildlife
S. Webb, R. Taalman, R. Becker, K. Onuma, and K. Igarashi
p. 2575 [Abstract] [full text - pdf 189KB]

Endocrine active substances and the need to improve environmental protection: An environmentalist's perspective
G. Lyons
p. 2593 [Abstract] [full text - pdf 157KB]

Endocrine disruption and the USFDA's Center for Drug Evaluation and Research
A. Jacobs, P. Brown, J. Farrelly, J. E. Fisher, and D. Morse
p. 2605 [Abstract] [full text - pdf 129KB]

Relevant activities for risk management of endocrine disruptors in Japanese government agencies
S. Oikawa and M. Matsumoto
p. 2609 [Abstract] [full text - pdf 112KB]

Advancing the testing and assessment of chemical substances for endocrine disruption: OECD activities
H. B. W. M. Koëter
p. 2613 [Abstract] [full text - pdf 110KB]

*Corresponding author and co-editor of this publication: Joanna Burger <Burger@Biology.Rutgers>


> link to corresponding project

Page last modified 30 January 2004.
Copyright © 2004 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact web manager.