Glyoxylic acid derivatives in asymmetric synthesis*
Janusz Jurczak1,2 and Tomasz Bauer1
1Department of Chemistry,
University of Warsaw, Pasteura 1, PL-02-093 Warsaw, Poland;
2Institute of Organic Chemistry, Polish Academy of Sciences,
Kasprzaka 44/52, PL-01-224 Warsaw, Poland
Abstract: Synthesis of chiral derivatives of glyoxylic acid
with special emphasis on N-glyoxyloyl-(2R)-bornane-10,2-sultam is presented.
Investigation of glyoxylic acid chiral derivatives in various stereocontrolled
organic syntheses showed their excellent ability to provide products
of high optical purity. Application of our methodology to the synthesis
of natural products and their analogs is presented.
*Lecture presented at the 13th International
Conference on Organic Synthesis (ICOS-13), Warsaw, Poland, 1-5 July
2000.
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