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Pure Appl. Chem. Vol. 73, No. 6, pp. 993-1031 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 6

CHEMISTRY AND HUMAN HEALTH DIVISION
CLINICAL CHEMISTRY SECTION
COMMISSION ON TOXICOLOGY

Risk assessment for occupational exposure to chemicals. A review of current methodology (IUPAC Technical Report)

Robert F. M. Herber1, John H. Duffus*2, Jytte Molin Christensen3, Erik Olsen3, and Milton V. Park2

1Coronel Institute for Occupational and Environmental Health, Academic Medical Center, University of Amsterdam, P.O. Box 22700, NL1100 DE Amsterdam, The Netherlands; 2The Edinburgh Centre for Toxicology, 43 Mansionhouse Road, Edinburgh EH9 2JD, United Kingdom; 3National Institute of Occupational Health, Lerso Parkalle 105, DK-2 100, Copenhagen, Denmark

Abstract: This paper reviews the methodology available for risk assessment of exposure to substances in the workplace. Assessment starts with the identification and classification of hazard, which must be related to the dose­effect and dose­response information available for the hazards identified. Once the potential for exposure has been characterized, it should be quantified and compared with an established safe exposure level. The degree to which it exceeds that level is a measure of the risk. Even if the assessed risk is regarded as acceptable, there is the possibility that the situation will change with time, so it is important to monitor potentially harmful exposures. Factors relevant to effective monitoring are reviewed. Addresses of Internet sites where further information may be obtained are listed along with further reading.

> Download full text of the report [pdf file - 327 KB]

> View corresponding project

*Corresponding author

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