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Pure Appl. Chem. 75(2-3), 179-186, 2003

Pure and Applied Chemistry

Vol. 75, Issue 2-3

Synthesis of carbohydrate-based antibiotics

C.-H. Wong, M. C. Bryan, P. T. Nyffeler, H. Liu, and E. Chapman

Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 9203, USA

Abstract: Tackling the problem of carbohydrate recognition is a subject of current interest. Our strategies in this regard include development of new methods for the synthesis of saccharides and sugar arrays for screening, design of D-peptides to target bacterial cell-surface sugars, preparation of mechanism-based inhibitors of the enzymes involved in the biosynthesis of saccharides and the synthesis of aminoglycoside mimetics to target RNA.

*Pure Appl.Chem. 75, 141�419 (2003). An issue of reviews and research papers based on lectures presented at the 23rd IUPAC International Symposium on the Chemistry of Natural Products, Florence, Italy, 28 July � 2 August 2002.


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