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Pure Appl. Chem. 75(10), 1383-1393, 2003

Pure and Applied Chemistry

Vol. 75, Issue 10

Rotaxanes and catenanes as prototypes of molecular machines and motors*

C. Dietrich-Buchecker, M.C. Jimenez-Molero, V. Sartor, and J.-P. Sauvage

Laboratoire de Chimie Organo-Minerale, UMR 7513 CNRS, Faculté de Chimie, Université Louis Pasteur, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France

Abstract: In the course of the last 20 years, our view on rotaxanes and catenanes has completely changed. Copper(I)-templated strategies, in particular, have allowed us to prepare catenanes on a real preparative scale, in a few chemical steps from commercially available compounds. A particularly significant improvement was the introduction of the recently developed ring-closing metathesis reaction, using Grubbs catalyst. The dynamic properties of rotaxanes and catenanes has been exploited to construct molecular systems for which one component can be set in motion under the action of an external signal, while the other components can be considered as motionless (artificial molecular “machines ”and “motors ”). A particularly representative example is that of a rotaxane dimer, whose overall length can be controlled chemically: A metal exchange reaction (CuI/ZnII) triggers a reversible contraction/stretching process of the same molecular assembly, in a way reminiscent of the functioning of biological muscles.

*Lecture presented at the IUPAC Polymer Conference on the Mission and Challenges of Polymer Science and Technology (IUPAC PC2002), Kyoto, Japan, 2-5 December 2002. Other presentations are published in this issue, pp. 1359-1402.

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