Identifying the causative agents: The use of combined chemical and
biological strategies in monitoring programs
E. J. Routledge
Department of Biological Sciences, Brunel University,
Uxbridge, Middlesex, UB8 3PH,UK
Abstract: The toxicity identification and evaluation (TIE) approach
that identified unconjugated natural and synthetic steroid estrogens
to be the major estrogenic component in domestic sewage treatment work
effluent is described. Given the increasing popularity of TIE-based
approaches in ecotoxicology research, a number of important considerations,
limitations, and possible future directions of TIE studies are also
discussed.
*Report from a SCOPE/IUPAC project: Implication of
Endocrine Active Substances for Human and Wildlife (J. Miyamoto and
J.Burger, editors). Other reports are published in this issue,
pp. 1617-2615.
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