Polysaccharide derivatives as useful chiral stationary phases in high-performance liquid chromatography*
Xiaoming Chen1, Chiyo Yamamoto2, and Yoshio Okamoto1
1EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; 2Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Abstract: The chromatographic separation of enantiomers using chiral stationary phases (CSPs) has significantly advanced. The esters and carbamates of polysaccharides coated on silica gel have been extensively studied and widely used as CSPs for high-performance liquid chromatography (HPLC). In order to overcome the strict solvent limitation on these coated CSPs, the preparation of a new generation of CSPs consisting of immobilized polysaccharide derivatives has become increasingly important. The universal solvent compatibility of the new CSPs provides flexibility in both analytical and preparative chromatographies.
Keywords: polysaccharide; chirality; chiral stationary phase; chiral separation; HPLC.
*Paper based on a presentation at the 12th International Conference on Polymers and Organic Chemistry 2006 (POC'06), 2-7 July 2006, Okazaki, Japan. Other presentations are published in this issue, pp. 1471-1582.