H-Phosphonates: Versatile synthetic precursors to biologically active phosphorus compounds*
Adam Kraszewski1 and Jacek Stawinski1,2
1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland; 2Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-10691 Stockholm, Sweden
Abstract: In this review, a short account of H-phosphonate chemistry and its application to the synthesis of biologically important phosphates and their analogs is given.
Keywords: H-phosphonates; phosphate analogs; biological activity; nucleic acids; drugs.
*Invited contribution to a collection of papers for the IUPAC project 2005-042-1-300 "Chemistry for Biology". Other contributions to the project are published in this issue, pp. 2179-2366.