Thermodynamics and non/equilibrium criteria for development
and application of supplemented phase diagrams

Database
  3. The impact of phase transitions on stability

3.a
Biomolecule stability

3.b Dynamic Changes
      Structural collapse
      Chemical reactions
      Diffusion / Molecular mobility

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


3.a Biomolecule stability

  • Allison, S.D., Randolph, T.W., Manning, M.C., Middleton, K., Davis, A., and Carpenter, J.F. 1998. Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition. Arch. Biochem. Biophys. 358:171-181
  • Allison, S.D., Manning, M.C., Randolph, T.W., Middleton, K., Davis, A., and Carpenter, J.F. 2000. Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran. J. Pharm. Sci. 89:199-214.
  • Anchordoquy, T.J. and Carpenter, J.F. 1996. Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state. Arch. Biochem. Biophys. 332:231-238
  • Arakawa, T., Prestrelski, S.J., Kenney, W.C., and Carpenter, J.F. 1993. Factors affecting short-term and long-term stabilities of proteins. Adv. Dryg Deliv. Rev. 10:1-28.
  • Auh, J.H., Kim, Y.R., Cornillon, P., Yoon, J., Yoo, S.H., and Park, K.H. 2003. Cryoprotection of protein by highly concentrated branched oligosaccharides. Int. J. Food Sci. Technol. 38:553-563.
  • Bell, L.N., Hageman, M.J., and Bauer, J. 1995a. Impact of moisture on thermally induced denaturation and decomposition of lyophilized bovine somatotropin. Biopolymers 35:201-209.
  • Bell, L.N., Hageman, M.J., and Muraoka, L.M. 1995b. Thermally induced denaturation of lyophilized bovine somatotropin and lysozyme as impacted by moisture and excipients. J. Pharmaceut. Sci. 84:707-712.
  • Bell, L.N. and Hageman, M.J. 1996. Glass transition explanation for the effect of polyhydroxy compounds on protein denaturation in dehydrated solids. J. Food Sci. 61:372-378.
  • Bell, L.N. 1997. Peptide stability in solids and solutions. Biotechnol. Prog. 13:342-346.
  • Buera, M.P., Rossi, S., Moreno, S., and Chirife, J. 1999. DSC confirmation that vitrification is not necessary for stabilization of the restriction enzyme EcoRI dried with saccharides. Biotech. Prog. 15:577-579.
  • Burin, L., Buera, M.P., Hough, G., and Chirife, J. 2002. Thermal resistance of beta-galactosidase in dehydrated dairy model systems as affected by physical and chemical changes. Food Chem. 76:423-430.
  • Cardona, S., Schebor, C., Buera, M.P., Karel, M., and Chirife, J. 1997. Thermal stability of invertase in reduced-moisture amorphous matrices in relation to glassy state and trehalose crystallization. J. Food Sci. 62:105-112.
  • Carpenter, J.F., Prestrelski, S.J., and Arakawa, T. 1993. Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. Arch. Biochem. Biophys. 303, 456-464.
  • Carpenter, J. F., Prestrelski, S. J., Anchordoguy, T. J., and Arakawa, T. 1994. Interactions of stabilizers with proteins during freezing and drying. In "Protein Formulations and Delivery" (J. L. Cleland and R. S. Langer, eds.), pp. 134-147. ACS Symp. Ser. 567, ACS Books, Washington, DC.
  • Carpenter, J.F., Izutsu, K.I., and Randolph, T.W. 1996. Freezing- and drying- induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives. In Freeze-Drying/ Lyophilization of Pharmaceutical and Biological Products, eds. L. Rey and J.C. May, Marcel Dekker, NY, pp. 123-160.
  • Carpenter, J.F., Pikal, M.J., Chang, B.S., and Randolph, T.W. 1997. Rational design of stable lyophilized protein formulations: some practical advice. Pharm. Res. 14:969-975.
  • Chang, B.S. and Randall, C.S. 1992. Use of subambient thermal analysis to optimize protein lyophilization. Cryobiol., 29, 632-656.
  • Chang, B.S. and Fischer, N.L. 1995. Development of an efficient single-step freeze-drying cycle for protein formulations. Pharmaceut. Res. 12:831-837.
  • Chang, B.S., Beauvais, R.M., Dong, A., and Carpenter, J.F. 1996. Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation. Arch. Biochem. Biophys. 331:249-258.
  • Chang, B.S., Reeder, G., and Carpenter, J.F. 1996. Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist. Pharm. Res. 13:243-249.
  • Chen, Y.H., Aull, J.L., and Bell, L.N. 1999. Solid-state tyrosinase stability as affected by water activity and glass transition. Food Res. Int. 32:467-472.
  • Colaco, C., Sen, S., Thangavelu, M., Pinder, S. and Roser, B. 1992. Extraordinary stability of enzymes dried in trehalose: simplified molecular biology. Bio/Technol., 10, 1007-1011.
  • Colaco, C.A.L.S., Smith, C.J.S., Sen, S., Roser, D.H., Newman, Y., Ring, S. and Roser, B.J. 1994. Chemistry of protein stabilization by trehalose. In Formulation and Delivery of Proteins and Peptides (J.L. Cleland and R.S. Langer, eds.), pp. 222-240. ACS Symp. Ser. #567, ACS Books, Washington, DC.
  • Davidson, P. and Sun, W.Q. 2001. Effect of sucrose/raffinose mass ratios on the stability of co-lyophilized protein during storage above the Tg. Pharm. Res. 18:474-479.
  • Finney, J.L. & Poole, P.L. 1984. Protein Hydration and Enzyme Activity: Role of Hydration-Induced Conformation and Dynamic Changes in Activity of Lysozyme. Comments Mol. Cell. Biophys. 2, 129-51.
  • Ford, A. W., and Dawson, P. J. 1993. The effect of carbohydrate additives in the freeze-drying of alkaline phosphatase. J. Pharm. Pharmacol. 45, 86-93.
  • Fox, K.C. 1995. Biopreservation: putting proteins under glass. Science 267, 31 March, 1922-1923.
  • Franks, F. 1987. Protein Stability and Function at Low Temperatures. Cryo -Letters 8, 108-15.
  • Franks, F., Asquith, M.H., Hammond, C.C., Skaer, H.B. and Echlin, P. 1977, Polymeric cryoprotectants in the preservation of biological ultrastructure. I., Journal of Microscopy, 110(3), 223-38.
  • Franks, F. 1994. Effects of sucrose addition on recovery of lipoprotein(a) from lyophilized preparations. Clinical Chem. 40, 502.
  • Franks, F., Hatley, R.H.M. & Friedman, H.L. 1988. Thermodynamics of Protein Stability: Cold Destabilization as a General Phenomenon. Biophys. Chem. 31, 307-315.
  • Gottfried, D.S., Peterson, E.S., Sheikh, A.G., Wang, J., Yang, M., and Friedman, J.M. 1996. Evidence for damped hemoglobin dynamics in a room temperature trehalose glass. J. Phys. Chem. 100:12034-12042.
  • Hatley, R.H.M., Franks, F. & Mathias, S.F. 1987. Stabilization of Labile Biochemicals by Undercooling. Process Biochem. 22, 169-72.
  • Hatley, R.H.M. and Blair, J.A. 1999. Stabilization and delivery of labile materials by amorphous carbohydrates and their derivatives. J. Mol. Catal. B: Enzym. 7:11-19.
  • Imamura, K., Ogawa, T., Sakiyama, T., and Nakanishi, K. 2003. Effects of types of sugar on the stabilization of protein in the dried state. J. Pharm. Sci. 92:266-274.
  • Izutsu, K.I., Yoshioka, S., and Takeda, Y. 1991. The effects of additives on the stability of freeze-dried beta-galactosidase stored at elevated temperature. Int. J. Pharm. 71:137-146.
  • Izutsu, K., Yoshioka, S., and Terao, T. 1993. Decreased protein-stabilizing effects of cryoprotectants due to crystallization. Pharm. Res. 10, 1232-1237.
  • Izutsu, K., Yoshioka, S., and Kojima, S. 1994. Physical stability and protein stability of freeze-dried cakes during storage at elevated temperatures. Pharm. Res. 11, 995-999.
  • Izutsu, K., Yoshioka, S., and Terao, T. 1994. Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying. Chem. Pharm. Bull. 42: 5-8.
  • Izutsu, K., Yoshioka, S., and Kojima, S. 1995. Increased stabilizing effects of amphiphilic excipients on freeze-drying of LDH by dispersion into sugar matrices. Pharmaceut. Res. 12:838-843.
  • Izutsu, K.I. and Yoshioka, S. 1995. Stabilization of protein pharmaceuticals in freeze-dried formulations. Drug Stabil. 1:11-21.
  • Izutsu, K.I. and Kojima, S. 2002. Excipient crystallinity and its protein-structure-stabilizing effect during freeze-drying. J. Pharm. Pharmacol. 54:1033-1039.
  • Jiang, S. and Nail, S.L. 1998. Effect of process conditions on recovery of protein activity after freezing and freeze-drying. Europ. J. Pharm. Biopharm. 45:249-257.
  • Kreilgaard, L., Frokjaer, S., Flink, J.M., Randolph, T.W., and Carpenter, J.F. 1998. Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid. Arch. Biochem. Biophys. 360:121-134.
  • Kreilgaard, L., Frokjaer, S., Flink, J.M., Randolph, T.W., and Carpenter, J.F. 1999. Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid. J. Pharm. Sci. 88:281-290.
  • Lai, M.C. and Topp, E.M. 1999. Solid-state chemical stability of proteins and peptides. J. Pharm. Sci. 88:489-500.
  • Lai, M.C., Hageman, M.J., Schowen, R.L., Borchardt, R.T., and Topp, E.M. 1999. Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in PVAl and PVP matrixes. J. Pharm. Sci. 88:1073-1080.
  • Lai, M.C., Hageman, M.J., Schowen, R.L., Borchardt, R.T., Laird, B.B., and Topp, E.M. 1999. Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in PVP. J. Pharm. Sci. 88:1081-1089.
  • Levine, H. and Slade, L. 1988. Principles of Cryostabilization Technology from Structure/Property Relationships of Water-Soluble Food Carbohydrates - A Review. Cryo-Letters 9(1), 21-63.
  • Levine, H. and Slade, L. 1989. A Food Polymer Science Approach to the Practice of Cryostabilization Technology. Comments on Agricultural and Food Chemistry 1(6), 315-396.
  • Levine, H. and Slade, L. 1990. Cryostabilization Technology: Thermoanalytical Evaluation of Food Ingredients and Systems. In Thermal Analysis of Foods (eds. C.-Y. Ma & V.R. Harwalkar), Elsevier Applied Science, London, 221-305.
  • Levine, H. and Slade, L. 1992. Another view of trehalose for drying and stabilizing biological materials. BioPharm 5(4), 36-40.

  • Liao, Y.H., Brown, M.B., Nazir, T., Quader, A., and Martin, G.P. 2002. Effects of sucrose and trehalose on the preservation of the native structure of spray-dried lysozyme. Pharm. Res. 19:1847-1853.
  • MacDonald, G.A. and Lanier, T. 1991. Carbohydrates as cryoprotectants for meats and Surimi. Food Technol. 45(3): 150-159.
  • Mathias, S.F., Franks, F., and Hatley, R.H.M. 1991. The stabilization of proteins by freeze-drying and by alternative methods. In Polypeptide and Protein Drugs, pp. 120-131.
  • Mathlouthi, M., Larreta-Garde, V., Xu, Z.F., and Thomas, D. 1989. Solute-solvent and water activity of small carbohydrates: application to the study of enzyme stability in aqueous sugar solutions, J. Carbohydr. Chem., 8, 233-245.
  • Mattern, M., Winter, G., Rudolph, R., and Lee, G. 1997. Formulation of proteins in vacuum-dried glasses. 1. Improved vacuum-drying of sugars using crystallizing amino acids. Europ. J. Pharm. Biopharm. 44:177-185.
  • Mattern, M., Winter, G., Kohnert, U., and Lee, G. 1999. Formulation of proteins in vacuum-dried glasses. II. Process and storage stability in sugar-free amino acid systems. Pharm. Devel. Technol. 4:199-208
  • Mazzobre, M.F., Buera, M.P., and Chirife, J. 1997a. Glass transition and thermal stability of lactase in low-moisture amorphous polymeric matrices. Biotechnol. Prog. 13:195-199.
  • Mazzobre, M.F., Buera, M.P., and Chirife, J. 1997b. Protective role of trehalose on thermal stability of lactase in relation to its glass and crystal forming properties and effect of delaying crystallization. Lebens. wiss. Technol. 30:324-329.
  • Mazzobre, M.F. and Buera, M.D.P. 1999. Combined effects of trehalose and cations on the thermal resistance of á-galactosidase in freeze-dried systems. Biochim. Biophys. Acta 1473:337-344.
  • Mazzobre, M.F., Hough, G., and Buera, M.P. 2003. Phase transitions and functionality of enzymes and yeasts in dehydrated matrices. Food Sci. Tech. Int. 9:163-172.
  • Miller, D.P., Anderson, R.E., and de Pablo, J.J. 1998. The stabilization of lactate dehydrogenase and phosphofructokinase following freeze-thawing and vacuum-drying in the presence of trehalose and borate. Pharm. Res. 15:1215-1221.
  • Moreira, T., Pendas, J., Gutierrez, A., Pomes, R., Duque, J., and Franks, F. 1998. Effect of sucrose and raffinose on physical state and on lactate dehydrogenase activity of freeze-dried formulations. Cryo-Lett. 19:115-122.
  • Pikal, M. J., Dellerman, K. M., Roy, M. L., and Riggin, R. M. 1991. The effects of formulation variables on the stability of freeze-dried human growth hormone. Pharmaceut. Res. 8, 427-436.
  • Pikal, M. J., Dellerman, K., and Roy, M. L. 1991. Formulation and stability of freeze-dried proteins: effects of moisture and oxygen on the stability of freeze-dried formulations of human growth hormone. Develop. Biol. Standard. 74, 21-38.
  • Pikal, M.J. 1994. Freeze-drying of proteins: process, formulation, and stability. In Formulations and Delivery of Proteins and Peptides (J.L. Cleland and R.S. Langer, eds.), p. 120. ACS Symp. Ser. #567, ACS Books, Washington, DC.
  • Pikal, M.J. and Rigsbee, D.R. 1997. The stability of insulin in crystalline and amorphous solids: observation of greater stability for the amorphous form. Pharm. Res. 14:1379-1387.

  • Pikal, M.J. 1999. Mechanisms of protein stabilization during freeze-drying and storage: the relative importance of thermodynamic stabilization and glassy state relaxation dynamics. In Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products, eds. L. Rey and J.C. May, Marcel Dekker, NY, pp. 161-198.
  • Rasmussen, D. and Luyet, B., 1970. Contribution to the establishment of the temperature-concentration curves of homogeneous nucleation in solutions of some cryoprotective agents, Biodynamica 11, 33-44.
  • Rossi, S., Buera, M.P., Moreno, S., and Chirife, J. 1997. Stabilization of the restriction enzyme EcoRI dried with trehalose and other selected glass-forming solutes. Biotech. Prog. 13:609-616.
  • Roy, M. L., Pikal, M. J., Rickard, E. C., and Maloney, A. M. 1992. The effects of formulation and moisture on the stability of a freeze-dried monoclonal antibody-vinca conjugate: a test of the WLF glass transition theory. Dev. Biol. Stand. 74, 323-340.
  • Sastry, G.M. and Agmon, N. 1997. Trehalose prevents myoglobin collapse and preserves its internal mobility. Biochem. 36:7097-7108.
  • Schebor, C., Buera, M.P., Chirife, J. 1996. Glassy state in relation to the thermal inactivation of the enzyme invertase in amorphous dried matrices of trehalose, maltodextrin, and PVP. J. Food Eng. 30:269-282.
  • Schebor, C., Burin, L., Buera, M.P., Aguilera, J.M., and Chirife, J. 1997. Glassy state and thermal inactivation of invertase and lactase in dried amorphous matrices. Biotechnol. Prog. 13:857-863.
  • Sultanbawa, Y. and Li-Chan, E.C.Y. 1998. Cryoprotective effects of sugar and polyol blends in ling cod surimi during frozen storage. Food Res. Int. 31:87-98.



    3.b Dynamic Changes.Structural collapse.Chemical reactions.Diffusion/Molecular mobility

  • Al-Malah, K.I.M., Abu-Jdayil, B., Zaitoun, S., and Ghzawi, A.A.M. 2001. Application of WLF and Arrhenius kinetics to rheology of selected dark-colored honey. J. Food Proc. Eng. 24:341-357
  • Baik, M.Y. and Chinachoti, P. 2000. Moisture redistribution and phase transitions during bread staling. Cereal Chem. 77:484-488.
  • Baik, M.Y. and Chinachoti, P. 2003. Water self-diffusion coefficient and staling of white bread as affected by glycerol. Cereal Chem. 80:740-744.
  • Baik, M.Y., Dickinson, L.C., and Chinachoti, P. 2003. Solid-state 13C CP/MAS NMR studies on aging of starch in white bread. J. Agric. Food Chem. 51:1242-1248.
  • Baker, L.A. and Rayas-Duarte, P. 1998. Freeze-thaw stability of amaranth starch and the effects of salt and sugars. Cereal Chem. 75:301-307.
  • Baker, L.A. and Rayas-Duarte, P. 1998. Retrogradation of amaranth starch at different storage temperatures and the effects of salt and sugars. Cereal Chem. 75:308-314.
  • Berglund, P.T. and Shelton, D.R. 1993. Effect of frozen storage duration on firming properties of breads baked from frozen doughs. Cereal Foods World 38, 89-93.
  • Bevilacqua, A.E. and Zaritzky, N.E. 1982, Ice Recrystallization in Frozen Beef, Journal of Food Science, 47, 1410-1414.
  • Bhandari, B.R. and Howes, T. 2000. Glass transition in processing and stability of food. Food Australia 52:579-585.
  • Bhattacharya, M. & Hanna, M.A.. 1987. Kinetics of Starch Gelatinization During Extrusion Cooking. J. Food Sci. 52, 764-66.
  • Bhandari, B., D'Arcy, B., and Kelly, C. 1999. Rheology and crystallization kinetics of honey: present status. Int. J. Food Prop. 2:217-226.
  • Bell, L.N. and Hageman, M.J. 1994. Differentiating between the effects of water activity and glass transition-dependent mobility on a solid-state chemical reaction: aspartame degradation. J. Agric. Food Chem. 42, 2398-2401.
  • Bell, L.N. and Hageman, M.J. 1995. A model system for differentiating between water activity and glass transition effects on solid state chemical reactions. J. Food Qual. 18:141-147.
  • Bell, L.N. 1995. Investigations regarding the determination of Tgs from moisture sorption isotherms. Drug Devel. Indust. Pharm. 21:1649-1659.
  • Bell, L.N. 1996. Kinetics of non-enzymatic browning in amorphous solid systems: distinguishing the effects of water activity and the glass transition. Food Res. Int. 28:591-597.
  • Bell, L.N., Touma, D.E., White, K., and Chen, Y. 1998. Glycine loss and Maillard browning as related to the glass transition in a model food system. J. Food Sci. 63:625-628.
  • Bell, L.N., White, K.L., and Chen, Y.H. 1998. Maillard reaction in glassy low- moisture solids as affected by buffer type and concentration. J. Food Sci. 63:785-788.
  • Bell, L.N. and White, K.L. 2000. Thiamin stability in solids as affected by the glass transition. J. Food Sci. 65:498-501.
  • Beristain, C.I., Azuara, E., and Vernon-Carter, E.J. 2002. Effect of water activity on the stability to oxidation of spray-dried encapsulated orange peel oil using mesquite gum as wall material. J. Food Sci. 67:206-211.
  • Beristain, C.I., Azuara, E., Tamayo, T.T., and Vernon-Carter, E.J. 2003. Effect of caking and stickiness on the retention of spray-dried encapsulated orange peel oil. J. Sci. Food Agric. 83:1613-1616
  • Brake, N.C. and Fennema, O.R. 1999. Lipolysis and lipid oxidation in frozen minced mackerel as related to Tg', molecular diffusion, and presence of gelatin. J. Food Sci. 64:25-32.
  • Biliaderis, C.G., Lazaridou, A., Mavropoulos, A., and Barbayiannis, N. 2002. Water plasticization effects on crystallization behavior of lactose in a co-lyophilized amorphous polysaccharide matrix and its relevance to the glass transition. Int. J. Food Prop. 5:463-482.
  • Blake, A. 1994. Flavor encapsulation with carbohydrate glasses. Food Ingred. Int. 3:30-34.
  • Blanshard, J.M.V. and Franks, F. 1987. Ice Crystallization and its Control in Frozen Food Systems. In Food Structure and Behaviour (eds J.M.V. Blanshard & P. Lillford), London, Academic Press, 51-65.
  • Blanshard, J.M.V., Muhr A.H, Gough, A. 1991. Crystallization from concentrated sucrose solutions. In: Water Relationships in Foods, ed Levine H, Slade L. Plenum Press, New York, pp 639-655.
  • Buera, M.P. and Karel, M. 1993. Application of the WLF equation to describe the combined effects of moisture and temperature on non-enzymatic browning rates in food systems. J. Food Proc. Preserv. 17, 31-45.
  • Buera, M.P. and Karel, M. 1994. Changes in optical properties of polymeric matrix systems undergoing glass transitions and non-enzymatic browning reactions. IFT '94 Annual Meeting, Atlanta, June 26.
  • Buera, M.P. and Karel, M. 1995. Effect of physical changes on the rates of non-enzymatic browning and related reactions. Food Chem. 52, 167-173.
  • Buera, M.P., Chirife, J., and Karel, M. 1995. A study of acid-catalyzed sucrose hydrolysis in an amorphous polymeric matrix at reduced moisture contents. Food Res. Int. 28:359-365.
  • Burin, L., Jouppila, K., Roos, Y., Kansikas, J., and Buera, M.D.P. 2000. Color formation in dehydrated modified whey powder systems as affected by compression and Tg. J. Agric. Food Chem. 48:5263-5268.
  • Burin, L.; Jouppila; K; Roos, J; Kansikas, J. and Buera P. 2004. Retention of beta-galctosidase activity as related to Maillard reaction. lactose crystallization, collapse and glass transition in low moisture whey systems. International Dairy Journal Ed. Elsevier. 14:517-525,

  • Burova, T.V., Grinberg, N.V., Grinberg, V.Y., and Tolstoguzov, V.B. 2003. Binding of odorants to individual proteins and their mixtures. Effects of protein denaturation and association. A plasticized globule state. Colloids & Surf. A:213:235-244.

  • Burros, B.C., Young, L.A. & Carroad, P.A. 1987. Kinetics of Corn Meal Gelatinization at High Temperature and Low Moisture. J. Food Sci. 52, 1372-80.
  • Byrn, S.R., Xu, W., and Newman, A.W. 2001. Chemical reactivity in solid-state pharmaceuticals: formulation implications. Adv. Drug Deliv. Rev. 48:115-136.
  • Cairns, P., Miles, M.J., and Morris, V.J. 1991. Studies of the effect of the sugars ribose, xylose, and fructose on the retrogradation of wheat starch gels by X-ray diffraction. Carbohydr. Polym. 16: 355-365.
  • Cairns, P., I'Anson, K.J., and Morris, V.J. 1991. The effect of added sugars on the retrogradation of wheat starch gels by X-ray diffraction. Food Hydrocolloids 5: 151-153.
  • Calligaris, S., Falcone, P., and Anese, M. 2002. Color changes of tomato purees during storage at freezing temperatures. J. Food Sci. 67:2432-2435.
  • Camacho, M.M., Martinez-Navarrete, N., and Chiralt, A. 2001. Stability of whipped dairy creams containing locust bean gum/lambda-carrageenan mixtures during freezing-thawing processes. Food Res. Int. 34:887-894.
  • Champion, D., Blond, G., and Simatos, D. 1997. Reaction rates at subzero temperatures in frozen sucrose solutions: a diffusion-controlled reaction. Cryo-Letters 18:251-260.
  • Champion, D., Blond, G., Le Meste, M., and Simatos, D. 2000. Reaction rate modeling in cryoconcentrated solutions: alkaline phosphatase catalyzed DNPP hydrolysis. J. Agric Food Chem. 48:4942-4947.
  • Champion, D., Le Meste, M., and Simatos, D. 2000. Towards an improved understanding of glass transition and relaxations in foods: molecular mobility in the glass transition range. Trends Food Sci. Technol. 11:41-55
  • Chang, Y.H., Lin, C.C., Wang, I.C., and Lii, C.Y. 1999. Kinetic study of the retrogradation rate of rice starch. Food Sci. Agric. Chem. 1:203-209.
  • Chang, S.-M. and Liu, L.-C. 1991. Retrogradation of rice starches studied by DSC and influence of sugars, NaCl, and lipids. J. Food Sci. 56: 564-566, 570.

  • Chatakanonda, P., Varavinit, S., and Chinachoti, P. 2000. Relationship of gelatinization and recrystallization of crosslinked rice to Tg. Cereal Chem. 77:315-319.

  • Chen, Y.H., Aull, J.L., and Bell, L.N. 1999. Invertase storage stability and sucrose hydrolysis in solids as affected by water activity and glass transition. J. Agric. Food Chem. 47:504-509.

  • Chung, M.S., Ruan, R.R., Chen, P., Chung, S.H., Ahn, T.H., and Lee, K.H. 2000. Study of caking in powdered foods using NMR spectroscopy. J. Food Sci. 65:134-138.

  • Chung, M.S., Ruan, R., Chen, P., Lee, Y.G., Ahn, T.H., and Baik, C.K. 2001. Formulation of caking-resistant powdered soups based on NMR analysis. J. Food Sci. 66:1147-1151
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